I have recently been pondering the inevitable disappointment that writers suffer and the depression that may accompany it. Writers get rejected. Its a thing. It happens. To all writers regardless of skill or experience, despite what some recent popular novels might suggest. The natural reaction to rejection is disappointment that may spiral into depression, but writers must fight this downward spiral. It leads to excuses. Excuses lead to stopping writing. Stopping writing leads to despair. Despair leads to the dark side, or something like that.
The only cure for this badness is...wait for it...more writing. But people didn't like what I already wrote, how could they possibly like something else I write? (Said with a bit of a nasal whine). Here's the truth. The more you write, the better you get. Also, the more you write, the more material you have to offer to people to like. It is akin to buying several raffle tickets as opposed to just one. My advice, give yourself more chances to win (i.e. get published). Additionally, submit to more than one place. Eggs, basket, etc.
Again, in summary, in the face of disappointment, write more, submit more, submit to more places.
On a possibly related topic, the release of Moonlight Medicine: Epidemic has been pushed to Halloween 2014.
Keep Writing, Edit On.